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LMP744 hydrochloride

CAS No. 308246-57-3

LMP744 hydrochloride ( MJ-III65 hydrochloride; NSC706744 hydrochloride )

Catalog No. M26282 CAS No. 308246-57-3

LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LMP744 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?
  • Description
    LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?(In Vitro):LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.The GI50 value of LMP744 for NCI60 cells is 0.1 μM.?(In Vivo):LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.
  • Synonyms
    MJ-III65 hydrochloride; NSC706744 hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Topoisomerase
  • Recptor
    DNA-PKCS; Ku 70/80 heterodimer protein
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    308246-57-3
  • Formula Weight
    488.9
  • Molecular Formula
    C24H25ClN2O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.
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