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LMP744 hydrochloride
CAS No. 308246-57-3
LMP744 hydrochloride ( MJ-III65 hydrochloride; NSC706744 hydrochloride )
Catalog No. M26282 CAS No. 308246-57-3
LMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 215 | Get Quote |
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| 10MG | 335 | Get Quote |
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| 25MG | 561 | Get Quote |
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| 50MG | 799 | Get Quote |
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| 100MG | 1098 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLMP744 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionLMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?
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DescriptionLMP744 hydrochloride is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.?(In Vitro):LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle.The GI50 value of LMP744 for NCI60 cells is 0.1 μM.?(In Vivo):LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity.
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SynonymsMJ-III65 hydrochloride; NSC706744 hydrochloride
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PathwayCell Cycle/DNA Damage
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TargetTopoisomerase
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RecptorDNA-PKCS; Ku 70/80 heterodimer protein
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Research Area——
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Indication——
Chemical Information
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CAS Number308246-57-3
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Formula Weight488.9
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Molecular FormulaC24H25ClN2O7
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Weterings E, et al. A novel small molecule inhibitor of the DNA repair protein Ku70/80. DNA Repair (Amst). 2016 Jul;43:98-106.
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